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KMID : 1059520210650050327
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Journal of the Korean Chemical Society
2021 Volume.65 No. 5 p.327 ~ p.332
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Anti-inflammatory Polymethoxyflavones Isolated from the Branches of Shiranuhi Tree
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Jo Yeon-Jeong
Lee Nam-Ho
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Abstract
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Shiranuhi is a fruit of Citrus species widely cultivated in Jeju Island, Korea. From an extract of Shiranuhi tree branches were identified five polymethoxyflavones possessing anti-inflammatory effects; nobiletin (1), sinensetin (2), tetramethylscutellarein (3), 6-hydroxy-5,7,3′,4′-tetramethoxyflavone (4) and 5-desmethylsinensetin (5). Evaluation of the activities was conducted by monitoring the production of nitric oxide (NO), prostaglandin E2 and pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) as well as the levels of iNOS and COX-2 protein expression in LPS-induced RAW264.7 cells. Among the isolates, the compound 4 exhibited the most significant NO inhibition, and suppressed the levels of iNOS and related cytokines.
Therefore, it was suggested that the extract and constituents from Shiranuhi tree branches could be useful as antiinflammatory ingredient.
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KEYWORD
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Shiranuhi, Polymethoxyflavone, Isolation, Anti-inflammation
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